Many bacteria conditionally express proteinaceous organelles referred to here as microcompartments (Fig. 1). These microcompartments are thought to be involved in a least seven different metabolic processes and the number is growing. Microcompartments are very large and structurally sophisticated. They are usually about 100–150 nm in cross section and consist of 10,000–20,000 polypeptides of 10–20 types. Their unifying feature is a solid shell constructed from proteins having bacterial microcompartment (BMC) domains. In the examples that have been studied, the microcompartment shell (...) encases sequentially acting metabolic enzymes that catalyze a reaction sequence having a toxic or volatile intermediate product. It is thought that the shell of the microcompartment confines such intermediates, thereby enhancing metabolic efficiency and/or protecting cytoplasmic components. Mechanistically, however, this creates a paradox. How do microcompartments allow enzyme substrates, products and cofactors to pass while confining metabolic intermediates in the absence of a selectively permeable membrane? We suggest that the answer to this paradox may have broad implications with respect to our understanding of the fundamental properties of biological protein sheets including microcompartment shells, S‐layers and viral capsids. BioEssays 30:1084–1095, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Given the importance of cross-disciplinary research, facilitating CDR effectiveness is a priority for many institutions and funding agencies. There are a number of CDR types, however, and the effectiveness of facilitation efforts will require sensitivity to that diversity. This article presents a method characterizing a spectrum of CDR designed to inform facilitation efforts that relies on bibliometric techniques and citation data. We illustrate its use by the Toolbox Project, an ongoing effort to enhance cross-disciplinary communication in CDR teams through structured, (...) philosophical dialogue about research assumptions in a workshop setting. Toolbox Project workshops have been conducted with more than 85 research teams, but the project's extensibility to an objectively characterized range of CDR collaborations has not been examined. To guide wider application of the Toolbox Project, we have developed a method that uses multivariate statistical analyses of transformed citation proportions from published manuscripts to identify candidate areas of CDR, and then overlays information from previous Toolbox participant groups on these areas to determine candidate areas for future application. The approach supplies 3 results of general interest: A way to employ small data sets and familiar statistical techniques to characterize CDR spectra as a guide to scholarship on CDR patterns and trends. A model for using bibliometric techniques to guide broadly applicable interventions similar to the Toolbox. A method for identifying the location of collaborative CDR teams on a map of scientific activity, of use to research administrators, research teams, and other efforts to enhance CDR projects. (shrink)

This is a book about sensory states and their apparent characteristics. It confronts a whole series of metaphysical and epistemological questions and presents an argument for type materialism: the view that sensory states are identical with the neural states with which they are correlated. According to type materialism, sensations are only possessed by human beings and members of related biological species; silicon-based androids cannot have sensations. The author rebuts several other rival theories, and explores a number of important issues: the (...) forms and limits of introspective awareness of sensations, the semantic properties of sensory concepts, knowledge of other minds, and unity of consciousness. The book is a significant contribution to the philosophy of mind, and has much to say to psychologists and cognitive scientists. (shrink)

This book presents a comprehensive theory of consciousness. The initial chapter distinguishes six main forms of consciousness and sketches an account of each one. Later chapters focus on phenomenal consciousness, consciousness of, and introspective consciousness. In discussing phenomenal consciousness, Hill develops the representational theory of mind in new directions, arguing that all awareness involves representations, even awareness of qualitative states like pain. He then uses this view to undercut dualistic accounts of qualitative states. Other topics include visual awareness, visual appearances, (...) emotional qualia, and meta-cognitive processing. This important work will interest a wide readership of students and scholars in philosophy of mind and cognitive science. (shrink)

Drawing on Ezekiel Emanuel’s controversial piece ‘Why I hope to die at 75,’ I distinguish two types of concern in ethical debates about extending the human lifespan. The first focusses on the value of living longer from prudential and social perspectives. The second type of concern, which has received less attention, focusses on the value of aiming for longer life. This distinction, which is overlooked in the ethical literature on life extension, is significant because there are features of human psychology (...) and the structure of a life that should give pause when considering how long one should aim to live, but which do not neatly coincide with considerations about how valuable additional life is likely to be. I argue that, while Emanuel’s case for hoping to die at 75 is unconvincing, he nonetheless provides weak pro tanto considerations in favour of taking a moderate life span as a prudential aim around which to base at least some significant life plans. (shrink)

In the first chapter of his Knowledge and Lotteries, John Hawthorne argues that thinkers do not ordinarily know lottery propositions. His arguments depend on claims about the intimate connections between knowledge and assertion, epistemic possibility, practical reasoning, and theoretical reasoning. In this paper, we cast doubt on the proposed connections. We also put forward an alternative picture of belief and reasoning. In particular, we argue that assertion is governed by a Gricean constraint that makes no reference to knowledge, and that (...) practical reasoning has more to do with rational degrees of belief than with states of knowledge. (shrink)

This volume presents a selection of essays by the leading philosopher Christopher S. Hill. Together, they address central philosophical issues related to four key concerns: the nature of truth; the relation between experiences and brain states; the relation between experiences and representational states; and problems concerning knowledge.

There is an important family of semantic notions that we apply to thoughts and to the conceptual constituents of thoughts - as when we say that the thought that the Universe is expanding is true. Thought and World presents a theory of the content of such notions. The theory is largely deflationary in spirit, in the sense that it represents a broad range of semantic notions - including the concept of truth - as being entirely free from substantive metaphysical and (...) empirical presuppositions. At the same time, however, it takes seriously and seeks to explain the intuition that there is a metaphysically or empirically 'deep' relation linking thoughts to reality. Thus, the theory represents a kind of compromise between deflationism and versions of the correspondence theory of truth. This book will appeal to students and professionals interested in the philosophy of logic and language. (shrink)

As the subtitle indicates, this book is concerned with the relationship between consciousness and the physical world. It recommends a novel and disturbingly pessimistic view about this topic that it calls “naturalistic mysterianism.” The view is naturalistic because it maintains that states of consciousness are reducible to physical properties of the brain. It counts as “mysterian” because it asserts that the physical properties in question are entirely beyond our ken—that they lie well beyond the scope of contemporary neuroscience, and quite (...) likely beyond the scope of any body of scientific knowledge that we might develop in the future. Naturalistic mysterianism thus affirms the unity of consciousness with the physical world, while also claiming that the nature of that unity will forever elude us, due to inherent limits of our cognitive capacities. (shrink)

Visual experience is shaped by a number of factors that are independent of the external objects that we perceive—factors like lighting, angle of view, and the sensitivities of photoreceptors in the retina. This paper seeks to catalog, analyze, and explain the fluctuations in visual phenomenology that are due to such factors.

There are two main accounts of what it is for external objects to be presented in visual experience. According to particularism, particular objects are built into the representational contents of experiences. Existentialism is a quite different view. According to existentialism, the representational contents of perceptual experiences are general rather than particular, in the sense that the contents can be fully captured by existentially quantified statements. The present paper is a defense of existentialism. It argues that existentialism is much better equipped (...) than particularism to explain the contents of hallucinations, and it defends existentialism against three objections. (shrink)

There are two main accounts of what it is for external objects to be presented in visual experience. According to particularism, particular objects are built into the representational contents of experiences. Existentialism is a quite different view. According to existentialism, the representational contents of perceptual experiences are general rather than particular, in the sense that the contents can be fully captured by existentially quantified statements. The present paper is a defense of existentialism. It argues that existentialism is much better equipped (...) than particularism to explain the contents of hallucinations, and it defends existentialism against three objections. (shrink)

One of the strongest objections to the development and use of substantially life-extending interventions is that they would exacerbate existing unjust disparities of healthy lifespans between rich and poor members of society. In both popular opinion and ethical theory, this consequence is sometimes thought to justify a ban on life-prolonging technologies. However, the practical and ethical drawbacks of banning receive little attention, and the viability of alternative policies is seldom considered. Moreover, where ethicists do propose alternatives, there is scant effort (...) to consider their merits in light of developing world priorities. In response to these shortcomings, I distinguish four policy options and, on the basis of a plausible intuition about fairness, evaluate their implications for a fair distribution of healthy lifespans. I claim that even in developing nations it would be fairest to favor policies that promote equal access to at least one promising category of substantially life-extending intervention: calorie restriction mimetics. (shrink)

Schellenberg's book The unity of perception is full of innovative ideas and challenges to preconceptions. This discussion endorses several of Schellenberg's main contentions, but it also challenges her handling of several key topics, such as hallucinations and perceptual awareness of particulars, and it expresses doubts about the informativeness of her main analytic tool, the notion of a perceptual capacity.

The aim of this paper is to distinguish between, and examine, three issues surrounding Humphreys's paradox and interpretation of conditional propensities. The first issue involves the controversy over the interpretation of inverse conditional propensities — conditional propensities in which the conditioned event occurs before the conditioning event. The second issue is the consistency of the dispositional nature of the propensity interpretation and the inversion theorems of the probability calculus, where an inversion theorem is any theorem of probability that makes explicit (...) (or implicit) appeal to a conditional probability and its corresponding inverse conditional probability. The third issue concerns the relationship between the notion of stochastic independence which is supported by the propensity interpretation, and various notions of causal independence. In examining each of these issues, it is argued that the dispositional character of the propensity interpretation provides a consistent and useful interpretation of the probability calculus. (shrink)

Philosophical Issues, Volume 30, Issue 1, Page 175-191, October 2020.

In this book, Christopher Celenza provides an intellectual history of the Italian Renaissance during the long fifteenth century, from c.1350–1525. His book fills a bibliographic gap between Petrarch and Machiavelli and offers clear case studies of contemporary luminaries, including Leonardo Bruni, Poggio Bracciolini, Lorenzo Valla, Marsilio Ficino, Angelo Poliziano, and Pietro Bembo. Integrating sources in Italian and Latin, Celenza focuses on the linked issues of language and philosophy. He also examines the conditions in which Renaissance intellectuals operated in an (...) era before the invention of printing, analyzing reading strategies and showing how texts were consulted, and how new ideas were generated as a result of conversations, both oral and epistolary. The result is a volume that offers a new view on both the history of philosophy and Italian Renaissance intellectual life. It will serve as a key resource for students and scholars of early modern Italian humanism and culture. (shrink)

We present some teaching materials for metaphysics which use the method of introducing issues via puzzles, paradoxes, problems, and conundrums in metaphysics. The method is motivated by the aim to increase student participation and engagement in metaphysical issues so that the student considers and understands philosophical theories based on specific metaphysical concepts. These materials are a result of distilling first and second year undergraduate academic materials into simple presentations that retain the core focus on salient concepts. The presented teaching methods (...) share the same approach as Raymond Smullyan's puzzle-first approach to teaching. Potential goals for the material are numerous; one main goal is the development of the individual student's independent, original, and creative philosophical thinking and analysis as applied to the area of metaphysics. Other goals include the appreciation of overlap between different subareas within metaphysics - overlaps that we note. The article finishes with a further consideration of the importance and utilization of the emotions elicited from materials of philosophical problems and how these can be best incorporated into the teaching methods. (shrink)

My goal is to formulate a theory of introspection that can be integrated with a strongly reductionist account of sensations that I have defended elsewhere. In pursuit of this goal, I offer a skeletal explanation of the metaphysical nature of introspection and I attempt to resolve several of the main questions about the epistemological status of introspective beliefs.

Chalmers’s anti-materialist argument runs as follows.

Renaissance, conspiracies, bonfires: Machiavelli's little-known youth -- Highs and lows : Machiavelli emerges -- Interlude : Machiavelli's letter -- The prince -- The discourses -- The comedy of life : letters and plays, wives and lovers -- History -- Ghosts.

Lapo da Castiglionchio the Younger was a Florentine Renaissance humanist who died in 1438 at the age of thirty-three. He took part in one of the most interesting phases of Italian Renaissance humanism and achieved in his short lifetime a modest reputation as a first-rate Greek to Latin translator. Less well known is the fact that he wrote a fair amount of prose works. One of the most interesting of these is a treatise which he composed in the year of (...) his death, entitled De curie commodis, or, On the Benefits of the Curia, a portrait of the papal Curia which is written elegantly, learnedly, earnestly, and angrily. ;The goal of this study is to discuss this dialogue in its intellectual and social contexts; there are three chapters. The first is a general introduction to Lapo's life and work, to the dialogue itself, and to the historiography on the De curie commodis. The second chapter discusses the manner in which Lapo employs the virtues in a Stoicizing fashion as persuasive tools in the environment of Italian humanism. It is argued that his particular treatment of the virtues can serve as a key for interpreting the dialogue as a whole. The third chapter touches both on social historical issues in the De curie commodis and on Lapo's defense or curial wealth. ;There has been no adequate edition of the Latin text, based on a wide enough variety of extant manuscripts, nor has the De curie commodis ever been translated into English . Therefore, a thorough critical edition of the Latin text along with an annotated English translation follows the discussion. ;The treatise has been notoriously difficult to interpret and seems often to prevaricate. The interpretive conclusion of this study is that Lapo wrote as a well-informed but liminal figure in the socio-cultural environment of the papal Curia--as an outsider who desired to become a full-fledged insider. The De curie commodis is not the parting shot of a fed-up hanger-on; it is instead Lapo's last-ditch, highly critical but nonetheless sincere attempt to find a patron who would allow him to join a cultural ambient at which he marvelled but from which he felt himself unjustly excluded. (shrink)